国产高潮白浆无码,亚洲国产精品久久久久制服 ,久久亚洲伊人成综合人影院

<var id="s5eak"></var>

鄭重說明:

您值得信賴的中藥成分及標準合作伙伴滿足您研發和工業化需求

產品關鍵詞：香草酸-4-β-D-葡萄糖苷 6-甲氧基山奈酚茯苓新酸B 去甲異波爾定

guanyuwomen關于德思特

聯系方式

服務熱線：

028-8500-3950

公司傳真：	028-85589956
公司郵箱：	sales@tcmlmt.com
公司網址：	m.cbss.com.cn
公司地址：	四川省成都市溫江區?？坡肺鞫?28號5棟

發表文獻展示

當前位置:首頁關于德思特 > 發表文獻展示 >

Biomedical Chromatography-09 November 2018 款冬酮

時間：2020-09-03 瀏覽次數：分享到：

Pharmacokinetics and tissue distribution study of bisabolangelone from Angelicae Pubescentis Radix in rat using LC–MS/MS
期刊名：Biomedical Chromatography
文獻編號：DOI 10.1002/bmc.4433
文獻地址：https://onlinelibrary.wiley.com/doi/abs/10.1002/bmc.4433
發表日期：09 November 2018

Abstract
A sensitive and accurate LC–MS/MS method was established for quantifying bisabolangelone in rat plasma and tissues. Bisabolangelone was isolated and purified from Angelicae Pubescentis Radix. The pharmacokinetic and tissue distribution of bisabolangelone after administration to rat was performed by LC–MS/MS. Separation was carried out on a C8 (4.6 × 100 mm, 1.8 μm) column. The MS/MS transitions of bisabolangelone and tussilagone (internal standard) were set at m/z 249.1 → 109.1 and m/z 391.4 → 217.4, respectively. The lower limit of quantification in plasma and other tissues ranged from 1 to 4 ng/mL. The biosamples were prepared using protein precipitation method with acetonitrile. The recovery was >92%. The results showed that values of maximum concentrations and area under the curve depended linearly on the studied doses (2.5, 5 and 7.5 mg/kg body weight). The other ingredients in Angelicae Pubescentis Radix extract possibly reduce the absorption of bisabolangelone in rat. Tissue distribution revealed that bisabolangelone was widely distributed in vivo. The highest and lowest concentrations of bisabolangelone were found in the stomach and in the brain, respectively. It was concluded that the newly established HPLC–MS/MS method was suitable to describe the pharmacokinetic characteristics of bisabolangelone in rat after administration

Tussilagone [internal standard (IS), purity > 98.9%] was purchased from Chengdu Desite Biological Technology Co., Ltd (Chengdu, China)

上一篇：Journal of Pharmaceutical and Biomedical Analysis-15 July 2019

下一篇：Journal of chromatography. A-3 September 2019 特女貞苷橄欖苦苷

Afrormosine CAS:550-79-8 中藥對照品標準品

產品編碼：DA0040產品名稱：Afrormosine英文名:AfrormosineCAS登錄...

国产日韩高清中文无码av,久久91热狠狠色精品一区,亚洲啪AV永久无码精品放毛片,99热这里只有是精品2